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An IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody

An IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody

chipab

Temelimab, an IgG4 Anti-Human Endogenous Retrovirus Monoclonal Antibody: An Early Progress Safety Evaluation

Introduction: Temelimab (beforehand often called GNbAC1) is an immunoglobulin (Ig) G4 monoclonal antibody that targets the human endogenous retroviral envelope protein HERV-W-Env, confirmed to be associated to the pathogenesis of certain autoimmune issues just like various sclerosis (MS) and kind 1 diabetes mellitus (T1D). By neutralizing HERV-W-Env, temelimab would possibly act as a disease-modifying treatment for these issues. It is at current in medical development for MS and T1D.
Methods: The safety knowledge on temelimab (along with potential infusion-related reactions, malignancies, pregnancies and antidrug antibodies) collected all through three part I and 4 part II medical trials was reviewed and is summarized on this text.
Outcomes: In all the expansion program, 54 healthful volunteers obtained single doses of temelimab in three part I analysis, and 334 MS or T1D victims obtained temelimab for a whole estimated publicity of 465 patient-years in 4 part II trials.
No variations had been seen between numbers of treatment-emergent opposed events (TEAEs) or extreme opposed events (SAEs) between treatment groups (along with placebo), and the number of SAEs was restricted.
Furthermore, no variations had been seen in laboratory evaluations, vital indicators, electrocardiogram (ECG), or bodily examinations between treatment groups. Unusual potential infusion-related reactions had been reported. Temelimab treatment was not associated to an elevated hazard of infections or infestations.
Conclusion: These outcomes advocate that treatment with temelimab was not associated with any particular form of AE. Whole, temelimab was safe and actually correctly tolerated over the examined dose fluctuate after repeated month-to-month administrations.
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anti-Resistin

YF-PA20030 100 ug
EUR 403
Description: Rabbit polyclonal to Resistin

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-Resistin (3G11)

YF-MA18965 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (3G5)

YF-MA18966 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (1G10)

YF-MA18967 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (5E8)

YF-MA18968 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (4B11)

YF-MA18969 200 ul
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (2H8)

YF-MA18970 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (4C8)

YF-MA18971 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (6H8)

YF-MA18972 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (4H8)

YF-MA18973 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin (6C3)

YF-MA18974 100 ug
EUR 363
Description: Mouse monoclonal to Resistin

Anti-Resistin/RETN Antibody

PA1473 100ug/vial
EUR 334

Anti-Resistin/RETN Antibody

PB9412 100ug/vial
EUR 294

Resistin

GT15031 100 ug
EUR 552

Resistin

RA19059 100 ul
EUR 376

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Recombinant Human Resistin

7-01519 5µg Ask for price

Recombinant Human Resistin

7-01520 25µg Ask for price

Recombinant Human Resistin

7-01521 1mg Ask for price

Human Resistin Antibody

32138-05111 150 ug
EUR 261

Resistin, human recombinant

4559-100
EUR 729

Resistin, human recombinant

4559-1000
EUR 5106

Resistin, human recombinant

4559-25
EUR 256

Human Resistin (RETN)

1-CSB-EP019573HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 25.6 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Resistin(RETN) expressed in E.coli

Canine Resistin(Resistin) ELISA Kit

QY-E70171 96T
EUR 426

Rabbit Anti-Human Resistin/FIZZ3 protein antiserum #3

RSTN13-S 100 ul
EUR 457

Resistin protein

30R-2640 25 ug
EUR 302
Description: Purified recombinant Human Resistin protein

Resistin protein

30R-2641 25 ug
EUR 317
Description: Purified recombinant Mouse Resistin protein

Resistin protein

30R-2642 25 ug
EUR 302
Description: Purified recombinant Rat Resistin protein

Resistin antibody

20R-1870 100 ug
EUR 673
Description: Rabbit polyclonal Resistin antibody

Resistin antibody

20R-1872 100 ug
EUR 673
Description: Rabbit polyclonal Resistin antibody

Resistin protein

30R-AR019 25 ug
EUR 273
Description: Purified recombinant Human Resistin protein

Resistin protein

30R-AR020 25 ug
EUR 273
Description: Purified recombinant Human Resistin protein

Resistin protein

30R-AR032 25 ug
EUR 273
Description: Purified recombinant Human Resistin protein

Resistin antibody

70R-12369 100 ug
EUR 403
Description: Rabbit polyclonal Resistin antibody

Resistin antibody

70R-12461 100 ug
EUR 403
Description: Rabbit polyclonal Resistin antibody

Resistin antibody

70R-12463 100 ug
EUR 403
Description: Rabbit polyclonal Resistin antibody

Resistin antibody

70R-14012 100 ug
EUR 322
Description: Affinity purified Rabbit polyclonal Resistin antibody

Resistin antibody

10R-R122A 500 ug
EUR 273
Description: Mouse monoclonal Resistin antibody

Resistin Antibody

5561-100
EUR 316

Resistin Antibody

5561-30T
EUR 146

Resistin Antibody

5997-100
EUR 316

Resistin Antibody

5997-30T
EUR 146

Resistin Antibody

5999-100
EUR 316

Resistin Antibody

5999-30T
EUR 146

Resistin antibody

70R-RG001 100 ug
EUR 349
Description: Affinity purified Goat polyclonal Resistin antibody

Resistin antibody

70R-RG003 50 ug
EUR 273
Description: Affinity purified Goat polyclonal Resistin antibody

Resistin antibody

70R-RG005 50 ug
EUR 273
Description: Affinity purified Goat polyclonal Resistin antibody

Resistin antibody

70R-RR018 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal Resistin antibody

Resistin antibody

70R-51393 100 ul
EUR 244
Description: Purified Polyclonal Resistin antibody

Resistin Protein

20-abx262050
  • EUR 4615.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug
  • Shipped within 5-10 working days.

Resistin Protein

20-abx262253
  • EUR 5826.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug
  • Shipped within 5-10 working days.

Resistin Protein

20-abx262254
  • EUR 5826.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug
  • Shipped within 5-10 working days.

Resistin Protein

20-abx262255
  • EUR 5826.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 25 ug
  • 5 ug
  • Shipped within 5-10 working days.

rHu Resistin

AK9086-0005 5µg Ask for price

rHu Resistin

AK9086-0025 25µg Ask for price

rHu Resistin

AK9086-0100 100µg Ask for price

rHu Resistin

AK9086-1000 1mg Ask for price

human Resistin ELISA KIT

201-12-0339 96 tests
EUR 440
  • This Resistin ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Recombinant Human Resistin Mutant

7-01525 2µg Ask for price

Recombinant Human Resistin Mutant

7-01526 10µg Ask for price

Recombinant Human Resistin Mutant

7-01527 1mg Ask for price

Human Resistin ELISA kit

55R-1714 1 kit
EUR 671
Description: ELISA kit for the detection of Human Resistin in the research laboratory

Human Resistin ELISA kit

55R-2127 96 tests
EUR 766
Description: ELISA Kit for detection of Resistin in the research laboratory

Human Resistin ELISA kit

55R-E50 96 wells
EUR 1178
Description: ELISA kit for the detection of Human Resistin in the research laboratory

Human Resistin ELISA KIT

CSB-E06884h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Resistin ELISA KIT

1-CSB-E06884h
  • EUR 602.00
  • EUR 4238.00
  • EUR 2256.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Resistin in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Resistin ELISA kit

E01R0351-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin ELISA kit

E01R0351-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin ELISA kit

E01R0351-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Resistin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Resistin (RETN) Protein

20-abx068871
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Human Resistin ELISA Kit

EHR0358 96Tests
EUR 521

human Resistin ELISA KIT

CN-04165H1 96T
EUR 442

human Resistin ELISA KIT

CN-04165H2 48T
EUR 293

Human Resistin (RETN) Protein

abx670217-25ug 25 ug
EUR 551
  • Shipped within 1 week.

Human Resistin (RETN) Protein

20-abx651562
  • EUR 1024.00
  • EUR 356.00
  • EUR 3376.00
  • EUR 1233.00
  • EUR 704.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Human Resistin ELISA kit

LF-EK50441 1×96T
EUR 659

Human Resistin ELISA Kit

LF-EK70021 1×96T
EUR 521

Resistin, human recombinant protein

P1051-.025 25 µg
EUR 313
Description: Resistance-to-insulin (Resistin), also known as adipocyte-specific secretory factor (ADSF), is a 10 kDa secreted cysteine-rich peptide hormone. Resistin is a tissue-specific cytokine and inhibits insulin?s ability to stimulate glucose uptake.

Resistin, human recombinant protein

P1051-.1 100 µg
EUR 877
Description: Resistance-to-insulin (Resistin), also known as adipocyte-specific secretory factor (ADSF), is a 10 kDa secreted cysteine-rich peptide hormone. Resistin is a tissue-specific cytokine and inhibits insulin?s ability to stimulate glucose uptake.

Resistin, human recombinant protein

P1051-1 1 mg
EUR 6522
Description: Resistance-to-insulin (Resistin), also known as adipocyte-specific secretory factor (ADSF), is a 10 kDa secreted cysteine-rich peptide hormone. Resistin is a tissue-specific cytokine and inhibits insulin?s ability to stimulate glucose uptake.

Resistin Human Recombinant Protein

PROTQ9HD89-1 Regular: 25ug
EUR 317
Description: 9.9 kDa protein containing 93 amino acid residues.

Recombinant Human Resistin Protein

PROTQ9HD89-4 25ug
EUR 317
Description: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The three known members of this family; Resistin, RELM-α and RELM-β share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that Resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that Resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that Resistin expression is severely suppressed in obesity and that it may act as a feedback regulator of Adipogenesis. Recombinant human Resistin is a 19.5 kDa disulfide-linked homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond.

Human Resistin ELISA Kit

RK00139 96 Tests
EUR 521

Rabbit Anti-Human Resistin/FIZZ3 IgG #2, aff pure

RSTN12-A 100 ug
EUR 482

Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy

 

Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway by the use of antibody is a potent approach for T cells remodeling.
Nonetheless, the effectivity of antibody is partly compromised by its extreme worth, instability, hazard of autoimmune sickness, and so forth. Small molecule inhibitors are attention-grabbing choices to antibodies.
However, tumor-specific provide of small molecule inhibitor to the aim website for enhancing the interruption of PD-L1/PD-1 pathway is not reported.
Herein, we designed a tumor-specific provide nanoplatform that will successfully ship the small molecule inhibitor to the precise aim website, drastically enhancing the blocking impression of PD-L1/PD-1 pathway.
Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), resulting in a HA-Ce6 conjugate (HC). The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to type BMS/HC micelles.
The aim property of HA, combined with the hyaluronidase-induced degradation of HA in tumor website, permits the as-prepared micelles with tumor-specific provide of BMS for blocking PD-L1/PD-1 pathway.
Cooperative treatment with the photosensitizer Ce6, the present therapeutic nanoplatform demonstrated wonderful photoimmunotherapy for tumor regression in distant tumors and lung metastasis.
This approach of tumor-specific provide of small molecule inhibitors provides an environment friendly pathway to strengthen the blocking efficacy of PD-L1/PD-1 on environment friendly photoimmunotherapy.

Preclinical Antitumor Train and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Affected person-Derived Xenografts

Guanylyl cyclase C (GCC) is a distinctive therapeutic aim with expression restricted to the apical side of epithelial cell tight junctions considered solely accessible by intravenously administered brokers on malignant tissues the place GCC expression is aberrant.
Throughout the present look at, we sought to evaluate the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated by the use of a peptide linker to the extraordinarily cytotoxic DNA alkylator, DGN549.
The in vitro binding, payload launch, and in vitro train of TAK-164 was characterised motivating in vivo evaluation. The efficacy of TAK-164 and the relationship to publicity, pharmacodynamic marker activation, and biodistribution was evaluated in xenograft fashions and first human tumor xenograft (PHTX) fashions.
We exhibit TAK-164 selectively binds to, is internalized by, and has potent cytotoxic leads to opposition to GCC-expressing cells in vitro.
A single intravenous administration of TAK-164 (0.76 mg/kg) resulted in important progress value inhibition in PHTX fashions of mCRC.
Furthermore, imaging analysis characterised TAK-164 uptake and train and confirmed optimistic relationships between GCC expression and tumor uptake which correlated with antitumor train.
Collectively, our information advocate that TAK-164 could be very energetic in various GCC optimistic tumors along with these refractory to TAK-264, a GCC-targeted auristatin ADC.
A sturdy relationship between uptake of 89Zr-labeled TAK-164, ranges of GCC expression and, most notably, response to TAK-164 treatment in GCC expressing xenografts and PHTX fashions.
These information supported the medical development of TAK-164 as part of a first-in-human medical trial (NCT03449030).
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