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Antibody-protein binding and conformational changes

Antibody-protein binding and conformational changes

chipab

Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to engineer a greater effector response

Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses.

However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.

On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction. The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.

Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. At school (B2), we discovered adjustments in the identical loop area with out the general distortion.

At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.

Consequently, structural evaluation of antibodies is essential for therapeutic improvement. Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.

 

chipab
chipab

PE anti-human CD16

E16FHP016-100 100 Tests
EUR 629
Description: Available in various conjugation types.

Anti-Human CD16 Antibody

101-M290 100 µg
EUR 399
Description: Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. In humans each group of receptors is encoded by 2 - 3 closely related genes designated A, B, and C. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Different Fc receptors can function as activators, as inhibitors, or as decoy receptors.

APC anti-human CD16

E16FHA016-025 25 tests
EUR 293.67
Description: Available in various conjugation types.

APC anti-human CD16

E16FHA016-050 50 tests
EUR 419.33
Description: Available in various conjugation types.

APC anti-human CD16

E16FHA016-100 100 Tests
EUR 629
Description: Available in various conjugation types.

FITC anti-human CD16

E16FHF016-025 25 tests
EUR 222.33
Description: Available in various conjugation types.

FITC anti-human CD16

E16FHF016-050 50 tests
EUR 317.67
Description: Available in various conjugation types.

FITC anti-human CD16

E16FHF016-100 100 Tests
EUR 496
Description: Available in various conjugation types.

Mouse Anti Human Cd16 Monoclonal Antibody,RPE

CABT-45642MH 100 TEST
EUR 852

PerCP anti-human CD16

E16FHR016-025 25 tests
EUR 563.33
Description: Available in various conjugation types.

PerCP anti-human CD16

E16FHR016-100 100 tests
EUR 1235
Description: Available in various conjugation types.

PerCP anti-human CD16

E16FHR016CX-025 25 tests
EUR 390
Description: Available in various conjugation types.

PerCP anti-human CD16

E16FHR016CX-100 100 tests
EUR 1061.67
Description: Available in various conjugation types.

Biotin anti-human CD16

E16FHB016-025 25 tests
EUR 231.67
Description: Available in various conjugation types.

Biotin anti-human CD16

E16FHB016-050 50 tests
EUR 330.67
Description: Available in various conjugation types.

Biotin anti-human CD16

E16FHB016-100 100 Tests
EUR 496
Description: Available in various conjugation types.

Biotin anti-human CD16

E16FHB016-100U 100 μg
EUR 330.67
Description: Available in various conjugation types.

Biotin anti-human CD16

E16FHB016-500U 500 μg
EUR 1086
Description: Available in various conjugation types.

Purified anti-human CD16

E16FHU016-100U 100 μg
EUR 190.67
Description: Available in various conjugation types.

Purified anti-human CD16

E16FHU016-500U 500 μg
EUR 572
Description: Available in various conjugation types.

human CD16

mab-SF-C048 0.2mg
EUR 180

Mouse Anti Human Cd16 Monoclonal Antibody,Biotin

CABT-45622MH 0.1 mg
EUR 852

CD16 Human, Antibody

GWB-83A580 0.2 mg Ask for price

anti- CD16 antibody

FNab10139 100µg
EUR 702
Description: Antibody raised against CD16

PE Anti-Human CD16 Antibody

DL20203F-20Tests 20Tests
EUR 192.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

PE Anti-Human CD16 Antibody

DL20203F-50Tests 50Tests
EUR 267.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

APC Anti-Human CD16 Antibody

DL20204F-20Tests 20Tests
EUR 192.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

APC Anti-Human CD16 Antibody

DL20204F-50Tests 50Tests
EUR 267.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

FITC Anti-Human CD16 Antibody

DL20202F-20Tests 20Tests
EUR 192.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

FITC Anti-Human CD16 Antibody

DL20202F-50Tests 50Tests
EUR 267.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

PE-Cy5 anti-human CD16

E16FHC016-025 25 tests
EUR 476.67
Description: Available in various conjugation types.

PE-Cy5 anti-human CD16

E16FHC016-100 100 tests
EUR 1083.33
Description: Available in various conjugation types.

PE-Cy7 anti-human CD16

E16FHN016-025 25 tests
EUR 563.33
Description: Available in various conjugation types.

PE-Cy7 anti-human CD16

E16FHN016-100 100 tests
EUR 1148.33
Description: Available in various conjugation types.

AF647 Anti-Human CD16 Antibody

DL20211F-20Tests 20Tests
EUR 237.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

AF647 Anti-Human CD16 Antibody

DL20211F-50Tests 50Tests
EUR 335
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

APC-Cy7 anti-human CD16

E16FHO016-025 25 tests
EUR 563.33
Description: Available in various conjugation types.

APC-Cy7 anti-human CD16

E16FHO016-100 100 tests
EUR 1148.33
Description: Available in various conjugation types.

Human CD16 Monoclonal antibody

16A2-100T 100 test
EUR 339.9

Human CD16 Monoclonal antibody

16F-100T 100 test
EUR 215.6

Human CD16 Monoclonal antibody

16F2-100T 100 test
EUR 240.9

Human CD16 Monoclonal antibody

16PE2-100T 100 test
EUR 273.9

Human CD16 Monoclonal antibody

16PU2-01MG 0,1 mg
EUR 163.9

PerCP-Cy5.5 anti-human CD16

E16FHS016-025 25 tests
EUR 650
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD16

E16FHS016-100 100 tests
EUR 1408.33
Description: Available in various conjugation types.

NE Purified anti-human CD16

E16FHY016-050U 50 μg
EUR 520
Description: Available in various conjugation types.

NE Purified anti-human CD16

E16FHY016-1000U 1 mg
EUR 2773.33
Description: Available in various conjugation types.

NE Purified anti-human CD16

E16FHY016-500U 500 μg
EUR 1516.67
Description: Available in various conjugation types.

Purified Anti-Human CD16 Antibody

DL20200F-100ug 100μg
EUR 402.5
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

Purified Anti-Human CD16 Antibody

DL20200F-25ug 25μg
EUR 185
Description: CD16 is known as low affinity IgG receptor III (FcγRIII). It is expressed as two distinct forms (CD16a and CD16b). CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI)-anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC).

UNE Purified anti-human CD16

E16FHZ016-1000U 1 mg
EUR 2275
Description: Available in various conjugation types.

CD16 (FcgRIII) Human, Antibody

GWB-74F2BC 0.1 mg Ask for price

Mouse Human CD16

E2790143 100ul
EUR 225
Description: Available in various conjugation types.

Anti-Hu CD16 PE

1P-646-T025 25 tests
EUR 121

Anti-Hu CD16 PE

1P-646-T100 100 tests
EUR 242

Anti-Hu CD16 PE

1P-214-T025 25 tests
EUR 121

Anti-Hu CD16 PE

1P-214-T100 100 tests
EUR 242

Anti-Hu CD16 PE

1P-399-T025 25 tests
EUR 121

Anti-Hu CD16 PE

1P-399-T100 100 tests
EUR 242

Anti-CD16/CD32 Antibody

E38A8954 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-CD16+CD32 antibody

MO16A(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16A(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V500) 500 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V500) 500 ug
EUR 60

Anti-Hu CD16 APC

1A-646-T025 25 tests
EUR 121

Anti-Hu CD16 APC

1A-646-T100 100 tests
EUR 242

Anti-Hu CD16 FITC

1F-214-T025 25 tests
EUR 99

Anti-Hu CD16 FITC

1F-214-T100 100 tests
EUR 198

Anti-Hu CD16 FITC

1F-399-T025 25 tests
EUR 99

Anti-Hu CD16 FITC

1F-399-T100 100 tests
EUR 198

Anti-Hu CD16 FITC

1F-646-T025 25 tests
EUR 99

Anti-Hu CD16 FITC

1F-646-T100 100 tests
EUR 198

Anti-Hu CD16 PerCP

PC-646-T025 25 tests
EUR 121

Anti-Hu CD16 PerCP

PC-646-T100 100 tests
EUR 242

PE Anti-human CD16 Antibody *3G8*

101611L0 25 tests
EUR 183
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PE Anti-human CD16 Antibody *3G8*

101611L0-25tests 25 tests
EUR 179
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PE Anti-human CD16 Antibody *3G8*

101611L1 100 tests
EUR 516
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

 

Antibody-enhanced hepatitis E virus nanofiltration in the course of the manufacture of human immunoglobulin

 

Background: Circulation of hepatitis E virus (HEV) in areas the place plasma is sourced for the manufacture of plasma-derived medicinal merchandise (PDMPs) has prompted verification of HEV clearance.
HEV exists as quasi lipid-enveloped (LE) and non-lipid-enveloped (NLE) types, which could be of relevance for HEV clearance from manufacturing processes of antibody-containing PDMPs with solvent/detergent (S/D) remedy upstream of additional clearance steps.
Research design and strategies: Presence of various HEV particles in shares utilized in clearance research was investigated, with nanofilters graded across the assumed HEV particle sizes and by gradient centrifugation.
HEV elimination by 35-nm nanofiltration was investigated within the presence or absence of HEV antibodies, in buffer in addition to in immunoglobulin (IG) manufacturing course of intermediates.
Outcomes: HEV particles in line with LE, NLE, and an “intermediate” (IM) phenotype, obtained after S/D remedy, had been seen in numerous HEV shares. Within the absence of HEV antibodies, log discount elements (LRFs) of 4.Zero and a couple of.5 had been obtained by 35-nm nanofiltration of LE and IM HEV, constant with the bigger and smaller sizes of those phenotypes.
Addition of HEV antibodies enhanced IM HEV elimination round 1000-fold (LRF, 5.6). Efficient (LRF, >4.eight and >4.0) HEV elimination was obtained for the nanofiltration processing step for IG intermediates with various HEV antibody content material.
Conclusion: HEV spikes utilized in clearance research must be rigorously chosen, as variations in physicochemical properties may have an effect on HEV clearance.
Antibody-mediated enhancement of HEV nanofiltration was demonstrated in IG course of intermediates even at low HEV antibody focus, illustrating the robustness of this manufacturing step.
Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to
engineer a greater effector response.
Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses. However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.
On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction.
The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.
Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. I
n class (B2), we discovered adjustments in the identical loop area with out the general distortion. At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.
Consequently, structural evaluation of antibodies is essential for therapeutic improvement.
Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.

Anti-Human IL-4 Antibody

101-M05 500 µg
EUR 246.75
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody

101-M508 100 µg
EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody

102-P34 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-human IL-4 antibody

STJ15100045 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti-human IL-4 antibody

STJ15100046 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti‐Human IL‐17A

E2790213 100ul
EUR 225
Description: Available in various conjugation types.

IL-4, Human

E34M006H 5 μg
EUR 155

Human IL-4

GWB-CB2917 0.01 mg Ask for price

Human IL-4

gAP-0227 1mg
EUR 450

Human Interleukin-4 (IL-4) Antibody

32184-05111 150 ug
EUR 215

anti- IL-4 antibody

FNab09861 100µg
EUR 658.5
Description: Antibody raised against IL-4

anti- IL-4 antibody

FNab04278 100µg
EUR 702
Description: Antibody raised against IL-4

anti- IL-4 antibody

FNab04279 100µg
EUR 702
Description: Antibody raised against IL-4

anti- IL-4 antibody

LSMab09861 100 ug
EUR 463.2

Anti-IL-4 Antibody

E38A8953 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-IL-4 Antibody

E38A8961 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-IL-4 Antibody

ER1706-55 100ul
EUR 189
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNFβ and IFN-γ, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2, and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

Anti-IL-4 antibody

PAab04278 100 ug
EUR 494.4

Anti-IL-4 antibody

STJ96510 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93699 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93700 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

PE Anti-Human IL-4 Antibody

DL22181F-20Tests 20Tests
EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody

DL22181F-50Tests 50Tests
EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody

DL22182F-20Tests 20Tests
EUR 245
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody

DL22182F-50Tests 50Tests
EUR 357.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Rat Anti-Human IL-4, Antibody

GWB-600465 0.5 mg Ask for price

Rat Anti-Human IL-4, Antibody

GWB-ACBDBA 0.5 mg Ask for price

Rat Anti-Human IL-4, Antibody

GWB-C54D97 0.5 mg Ask for price

FITC Anti-Human IL-4 Antibody

DL22180F-20Tests 20Tests
EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

FITC Anti-Human IL-4 Antibody

DL22180F-50Tests 50Tests
EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Purified Anti-Human IL-4 Antibody

DL22179F-100ug 100μg
EUR 290
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Purified Anti-Human IL-4 Antibody

DL22179F-25ug 25μg
EUR 177.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

mAb mouse anti-human IL-4

CT253 0.5 mg
EUR 312

mouse anti-human IL-4 mAb

E409C13-m100 100μL
EUR 395
Description: Available in various conjugation types.

Rabbit anti-Human IL-4(CAP)

RM17744 1000μg Ask for price

Rabbit anti-Human IL-4(DET)

RM17745 100μg Ask for price

Mouse Monoclonal anti-human IL-4

hAP-0404 100ug
EUR 250

Sheep Polyclonal anti-human IL-4

hAP-5265 50ug
EUR 400

human anti-human IL-2 mAb

E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb

E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-1β mAb

E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb

E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-12/IL-23 p40 mAb(3H2)

E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)

E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Human Interleukin-4 (IL-4)

1-CSB-EP011659HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

Interleukin-4 (IL-4) Human

GWB-2A39E4 0.01 mg Ask for price

IL-4, Interleukin-4, human

RC212-15 5ug
EUR 125.26

human anti-human IL-12/IL-23 p40 mAb(1G11)

E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-Interleukin-4 (IL-4) Antibody

Y108183 50 μg
EUR 455

rec IL-4 (human)

H-9630.0002 2.0µg
EUR 313.2

rec IL-4 (human)

H-9630.0010 10.0µg
EUR 1140

Human IL-4 Protein

abx060798-20ug 20 ug
EUR 560.4

Human IL-4 protein

PRP100273-100ug 100 μg
EUR 1029
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein

PRP100273-1mg 1 mg
EUR 7139
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein

PRP100273-20ug 20 μg
EUR 509
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein

PRP2017-100ug 100 μg
EUR 429
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein

PRP2017-10ug 10 μg
EUR 59
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein

PRP2017-1mg 1 mg
EUR 3739
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein

PRP2017-50ug 50 μg
EUR 249
Description: Human IL-4 protein, expressed in HEK293 Cells

Recombinant Human IL-4

6486 5 µg
EUR 194

IL-4, human recombinant

4137-10 each
EUR 333.6

IL-4, human recombinant

4137-1000 each
EUR 4444.8

IL-4, human recombinant

4137-50 each
EUR 836.4

Recombinant Human IL-4

HEILP-0401 5ug Ask for price

Recombinant Human IL-4

P0052 100ug
EUR 626.83
Description: Recombinant Human protein for IL-4

Recombinant Human IL-4

SJB02-03 10µg/vial
EUR 342

Recombinant Human IL-4

SJB02-05 100µg/vial
EUR 864

Recombinant Human IL-4

SJB02-06 30µg/vial
EUR 516

Recombinant human IL-4

rcyec-hil4 10 µg
EUR 156.45

human IL-10 / IL-4 (without plate)

M874022001 1 unit
EUR 244.37

human IL-10 / IL-4 (without plate)

M874030001 1 unit
EUR 266.67

Human IL-4 Antibody Pair Set

ABPR-ZB073 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human IL-4

Human IL-4 ELISA antibody pair

CT742-10 10-plate
EUR 656.4

Human IL-4 ELISA antibody pair

CT742-20 20-plate
EUR 1118.4

Polyclonal Anti- human IL-3 Antibody

GWB-BBP009 0.1 mg Ask for price

Polyclonal Anti- human IL-6 Antibody

GWB-BBP013 0.1 mg Ask for price

Polyclonal Anti- human IL-7 Antibody

GWB-BBP014 0.1 mg Ask for price

Anti-Rat IL-4 Antibody

104-P05 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Rat anti-IL-4 Antibody

DL99451A-100ul 100 ul
EUR 299
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Rat anti-IL-4 Antibody

DL99451A-50ul 50 ul
EUR 210
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Rat anti-IL-4 Antibody

DL99459A-100ul 100 ul
EUR 299
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Rat anti-IL-4 Antibody

DL99459A-50ul 50 ul
EUR 210
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Anti-IL-4 Antibody [A7D7]

HA601034 100ul
EUR 210
Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Polyclonal Anti- human IL-10 Antibody

GWB-BBP015 0.1 mg Ask for price

Anti-Mouse IL-4 Antibody

103-M422 100 µg
EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Mouse IL-4 Antibody

103-P14 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-mouse IL-4 antibody

STJ15100035 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-mouse IL-4 antibody

STJ15100036 500 µg
EUR 632.4
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.

Anti-mouse IL-4 antibody

STJ15100037 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-IL-4 alpha antibody

STJ97665 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.
Brenda


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