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Antibody-protein binding and conformational changes

Antibody-protein binding and conformational changes

chipab

Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to engineer a greater effector response

Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses.

However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.

On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction. The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.

Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. At school (B2), we discovered adjustments in the identical loop area with out the general distortion.

At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.

Consequently, structural evaluation of antibodies is essential for therapeutic improvement. Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.

 

chipab
chipab

Anti-CD16 antibody

STJ16100112 0.5 mL
EUR 649.2

Anti-CD16 antibody

STJ16100113 0.5 mL
EUR 730.8

Anti-CD16 antibody

STJ16100960 100 tests
EUR 628.8

Anti-CD16 antibody

STJ16101087 100 µg
EUR 424.8

Anti-CD16 antibody

STJ16101088 100 µg
EUR 424.8

Anti-CD16 antibody

STJ180039 0.1 ml
EUR 279.6

Anti-CD16 antibody

STJ180346 0.1 ml
EUR 265.2

Anti-CD16 antibody

STJ96992 200 µl
EUR 236.4
Description: CD16 is a protein encoded by the FCGR3A gene which is approximately 29 kDa. CD16 is localised to the cell membrane. It is involved in the immune response role of DAP12 receptors in NK cells, regulation of actin dynamics for phagocytic cup formation and the role of phospholipids in phagocytosis. It is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from circulation, as well as other antibody-dependent responses. CD16 is expressed on natural killer cells, macrophages, a subpopulation of T-cells, immature thymocytes and placental trophoblasts. Mutations in the FCGR3A gene may result in an immunodeficiency. STJ96992 was developed from clone Q32 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous CD16 protein.

Anti-CD16 antibody

STJ98738 200 µl
EUR 236.4
Description: Rabbit polyclonal to CD16.

Anti-CD16 (2B11)

YF-MA12975 50 ug
EUR 435.6
Description: Mouse monoclonal to CD16

Anti-CD16 (2B11)

YF-MA12976 200 ul
EUR 435.6
Description: Mouse monoclonal to CD16

Anti-Hu CD16 PE

1P-214-T025 25 tests
EUR 168

Anti-Hu CD16 PE

1P-214-T100 100 tests
EUR 288

Anti-Hu CD16 PE

1P-399-T025 25 tests
EUR 168

Anti-Hu CD16 PE

1P-399-T100 100 tests
EUR 288

Anti-Hu CD16 PE

1P-646-T025 25 tests
EUR 168

Anti-Hu CD16 PE

1P-646-T100 100 tests
EUR 288

Anti-Hu CD16 Purified

11-646-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-646-C100 0.1 mg
EUR 189.6

Anti-Hu CD16 Purified

11-382-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-382-C100 0.1 mg
EUR 189.6

Anti-Hu CD16 Purified

11-399-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-399-C100 0.1 mg
EUR 189.6

Anti-Hu CD16 APC

1A-646-T025 25 tests
EUR 168

Anti-Hu CD16 APC

1A-646-T100 100 tests
EUR 288

Anti-Hu CD16 Biotin

1B-214-C025 0.025 mg
EUR 146.4

Anti-Hu CD16 Biotin

1B-214-C100 0.1 mg
EUR 244.8

Anti-Hu CD16 Biotin

1B-646-C025 0.025 mg
EUR 146.4

Anti-Hu CD16 Biotin

1B-646-C100 0.1 mg
EUR 244.8

Anti-Hu CD16 FITC

1F-214-T025 25 tests
EUR 146.4

Anti-Hu CD16 FITC

1F-214-T100 100 tests
EUR 244.8

Anti-Hu CD16 FITC

1F-399-T025 25 tests
EUR 146.4

Anti-Hu CD16 FITC

1F-399-T100 100 tests
EUR 244.8

Anti-Hu CD16 FITC

1F-646-T025 25 tests
EUR 146.4

Anti-Hu CD16 FITC

1F-646-T100 100 tests
EUR 244.8

Anti-Hu CD16 Purified

11-214-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-214-C100 0.1 mg
EUR 189.6

anti-CD16 monoclonal antibody

063-A-01mg 0,1 mg
EUR 321
Description: anti-CD16 monoclonal antibody

anti-CD16 monoclonal antibody

063-A-1000ug 1000 ug
EUR 1539
Description: anti-CD16 monoclonal antibody

Anti-CD16/FCGR3A Antibody

A01408-1 100ug/vial
EUR 352.8

Anti-CD16+CD32 antibody

MO16A(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16A(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V500) 500 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V500) 500 ug
EUR 60

Anti-Hu CD16 PerCP

PC-646-T025 25 tests
EUR 168

Anti-Hu CD16 PerCP

PC-646-T100 100 tests
EUR 288

Mouse Monoclonal Anti-Human CD16, Unlabeled

CD16UL-100 100 ug
EUR 489.6

Mouse Anti Human Cd16 Monoclonal Antibody

CABT-45628MH 0.1 mg
EUR 639.6

Mouse Anti Human Cd16 Monoclonal Antibody

CABT-45641MH 0.2 mg
EUR 920.4

Rat Anti Human Cd16 Monoclonal Antibody

CABT-45643RH 0.2 mg
EUR 889.2

Purified Anti-human CD16 Antibody *HI16a*

10160000 100 ug
EUR 164

APC Anti-human CD16 Antibody *HI16a*

101601C0 25 tests
EUR 179

APC Anti-human CD16 Antibody *HI16a*

101601C1 100 tests
EUR 505

APC Anti-human CD16 Antibody *HI16a*

101601C2 500 tests
EUR 1887

FITC Anti-human CD16 Antibody *HI16a*

101601H0 100 tests
EUR 245

FITC Anti-human CD16 Antibody *HI16a*

101601H1 500 tests
EUR 918

TRITC Anti-human CD16 Antibody *HI16a*

101601I0 100 tests
EUR 245

TRITC Anti-human CD16 Antibody *HI16a*

101601I1 500 tests
EUR 918

PacBlue Anti-human CD16 Antibody *HI16a*

101601J0 100 tests
EUR 245

PacBlue Anti-human CD16 Antibody *HI16a*

101601J1 500 tests
EUR 918

PacOrange Anti-human CD16 Antibody *HI16a*

101601K0 100 tests
EUR 245

PacOrange Anti-human CD16 Antibody *HI16a*

101601K1 500 tests
EUR 918

PE Anti-human CD16 Antibody *HI16a*

101601L0 25 tests
EUR 179

PE Anti-human CD16 Antibody *HI16a*

101601L1 100 tests
EUR 505

PE Anti-human CD16 Antibody *HI16a*

101601L2 500 tests
EUR 1887

PerCP Anti-human CD16 Antibody *HI16a*

101601T0 25 tests
EUR 179

PerCP Anti-human CD16 Antibody *HI16a*

101601T1 100 tests
EUR 505

PerCP Anti-human CD16 Antibody *HI16a*

101601T2 500 tests
EUR 1887

Purified Anti-human CD16 Antibody *3G8*

10161000 100 ug
EUR 164

APC Anti-human CD16 Antibody *3G8*

101611C0 25 tests
EUR 179

APC Anti-human CD16 Antibody *3G8*

101611C1 100 tests
EUR 505

APC Anti-human CD16 Antibody *3G8*

101611C2 500 tests
EUR 1887

FITC Anti-human CD16 Antibody *3G8*

101611H0 100 tests
EUR 245

FITC Anti-human CD16 Antibody *3G8*

101611H1 500 tests
EUR 918

TRITC Anti-human CD16 Antibody *3G8*

101611I0 100 tests
EUR 245

TRITC Anti-human CD16 Antibody *3G8*

101611I1 500 tests
EUR 918

PacBlue Anti-human CD16 Antibody *3G8*

101611J0 100 tests
EUR 245

 

Antibody-enhanced hepatitis E virus nanofiltration in the course of the manufacture of human immunoglobulin

 

Background: Circulation of hepatitis E virus (HEV) in areas the place plasma is sourced for the manufacture of plasma-derived medicinal merchandise (PDMPs) has prompted verification of HEV clearance.
HEV exists as quasi lipid-enveloped (LE) and non-lipid-enveloped (NLE) types, which could be of relevance for HEV clearance from manufacturing processes of antibody-containing PDMPs with solvent/detergent (S/D) remedy upstream of additional clearance steps.
Research design and strategies: Presence of various HEV particles in shares utilized in clearance research was investigated, with nanofilters graded across the assumed HEV particle sizes and by gradient centrifugation.
HEV elimination by 35-nm nanofiltration was investigated within the presence or absence of HEV antibodies, in buffer in addition to in immunoglobulin (IG) manufacturing course of intermediates.
Outcomes: HEV particles in line with LE, NLE, and an “intermediate” (IM) phenotype, obtained after S/D remedy, had been seen in numerous HEV shares. Within the absence of HEV antibodies, log discount elements (LRFs) of 4.Zero and a couple of.5 had been obtained by 35-nm nanofiltration of LE and IM HEV, constant with the bigger and smaller sizes of those phenotypes.
Addition of HEV antibodies enhanced IM HEV elimination round 1000-fold (LRF, 5.6). Efficient (LRF, >4.eight and >4.0) HEV elimination was obtained for the nanofiltration processing step for IG intermediates with various HEV antibody content material.
Conclusion: HEV spikes utilized in clearance research must be rigorously chosen, as variations in physicochemical properties may have an effect on HEV clearance.
Antibody-mediated enhancement of HEV nanofiltration was demonstrated in IG course of intermediates even at low HEV antibody focus, illustrating the robustness of this manufacturing step.
Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to
engineer a greater effector response.
Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses. However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.
On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction.
The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.
Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. I
n class (B2), we discovered adjustments in the identical loop area with out the general distortion. At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.
Consequently, structural evaluation of antibodies is essential for therapeutic improvement.
Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.

anti- IL-4 antibody

FNab04279 100µg
EUR 702
Description: Antibody raised against IL-4

anti- IL-4 antibody

LSMab09861 100 ug
EUR 463.2

anti- IL-4 antibody

FNab09861 100µg
EUR 658.5
Description: Antibody raised against IL-4

Anti-IL-4 antibody

PAab04278 100 ug
EUR 494.4

Anti-IL-4 antibody

STJ96510 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93699 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93700 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Recombinant Human IL-17F Protein

PROTQ96PD4-4 25ug
EUR 380.4
Description: IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant human IL-17F is a disulfide-linked homodimer of 30.1 kDa, consisting of two 133 amino acid residue chains.

Recombinant Human IL-6 Protein

PROTP05231-4 20ug
EUR 380.4
Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Recombinant Human IL-3 Protein

PROTP08700-4 10ug
EUR 380.4
Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

Recombinant Human IL-2 Protein

PROTP60568-4 50ug
EUR 380.4
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

mAb mouse anti-human IL-4

CT253 0.5 mg
EUR 312

Recombinant Human IL-12 p80 Protein

PROTP29460-4 10ug
EUR 380.4
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Recombinant Human IL-13 Variant Protein

PROTP35225-4 10ug
EUR 380.4
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.

Human Interleukin-4 (IL-4)

1-CSB-EP011659HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

IL-4, Interleukin-4, human

RC212-15 5ug
EUR 125.26

Anti-mouse IL-4 antibody

STJ15100035 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-mouse IL-4 antibody

STJ15100036 500 µg
EUR 632.4
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.

Anti-mouse IL-4 antibody

STJ15100037 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-IL-4 alpha antibody

STJ97665 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody

STJ93702 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody

STJ93703 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Recombinant Human IL-16 (129 a.a.) Protein

PROTQ14005-4 10ug
EUR 380.4
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues.

IL-4

E13-015-1 10μg
EUR 193.2

IL-4

E13-015-2 50μg
EUR 606

IL-4

MO15071 500 ug
EUR 1092

IL-4

E21-050 10ug
EUR 411.6

IL-4

E21-D03 10ug
EUR 411.6

IL-4

E21-K15 10ug
EUR 411.6

pAb rabbit anti-human IL-4 receptor

CT248 0.5 mg
EUR 220.8

Recombinant Human IL-8 (72 a.a.) (CXCL8) Protein

PROTP10145-4 25ug
EUR 380.4
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

IL-4, human recombinant

4137-10
EUR 333.6

IL-4, human recombinant

4137-1000
EUR 4444.8

IL-4, human recombinant

4137-50
EUR 836.4

Human IL-4 Protein

abx060798-20ug 20 ug
EUR 560.4

Recombinant Human IL-4

P0052 100ug
EUR 626.83
Description: Recombinant Human protein for IL-4

rec IL-4 (human)

H-9630.0002 2.0µg
EUR 313.2

rec IL-4 (human)

H-9630.0010 10.0µg
EUR 1140

Recombinant Human IL-4

SJB02-03 10µg/vial
EUR 342

Recombinant Human IL-4

SJB02-05 100µg/vial
EUR 864

Recombinant Human IL-4

SJB02-06 30µg/vial
EUR 516

Interleukin-4/IL-4

E21-K74 10ug
EUR 411.6

Swine IL-10 Recombinant Protein

R00021-4 5ug/vial
EUR 310.8
Description: IL-10 is an anti-inflammatory cytokine and a member of the IL-10 family of cytokines, which have indispensable functions in many infectious and inflammatory diseases. Swine IL-10 Recombinant Protein is purified interleukin-10 produced in yeast.

Mouse IL-13 Recombinant Protein

R00077-4 5ug/vial
EUR 310.8
Description: IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Mouse IL-13 Recombinant Protein is purified interleukin-13 produced in yeast.

Feline IL-6 Recombinant Protein

R00102-4 5ug/vial
EUR 310.8
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Feline IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Feline IL-2 Recombinant Protein

R00387-4 5ug/vial
EUR 310.8
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Feline IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Mouse IL-17A Recombinant Protein

R00421-4 5ug/vial
EUR 310.8
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Mouse IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.

Dolphin IL-8 Recombinant Protein

R00423-4 5ug/vial
EUR 310.8
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Dolphin IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

Swine IL-21 Recombinant Protein

R00459-4 5ug/vial
EUR 310.8
Description: The cytokine interleukin-21 (IL-21) regulates the proliferation and differentiation of T and B lymphocytes, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. Swine IL-21 Recombinant Protein is purified interleukin-21 produced in yeast.

Equine IL-1ra Recombinant Protein

R00651-4 5ug/vial
EUR 310.8
Description: Interleukin-1 Receptor Antagonist Protein (IL-1F3, IL-1ra) belongs to the IL-1 family of cytokines, whose members play key roles in the development and regulation of inflammation. IL-1 receptor antagonist (IL-1ra; IL-1F3) reduces inflammation by blocking the binding of the agonist receptor ligands. Equine IL-1 Receptor Antagonist Recombinant Protein is purified interleukin-1 receptor antagonist protein (IL-1F3, IL-1ra) produced in yeast.

Human Interleukin-4 (IL-4) Antibody

32184-05111 150 ug
EUR 313.2

IL-7 Interleukin-7 Human Recombinant Protein, His Tag

PROTP13232-4 Regular: 10ug
EUR 380.4
Description: IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. ;The IL-7 His-Tag protein is purified by proprietary chromatographic techniques.

mAb mouse anti-rat IL-4

CT028 0.5 mg
EUR 312

mAb mouse anti-rat IL-4

CT029 0.5 mg
EUR 312

pAb rabbit anti-rat IL-4

CT058 0.5 mg
EUR 220.8

mAb mouse anti-monkey IL-4

CT103 0.5 mg
EUR 312

mAb rat anti-mouse IL-4

CT324 0.5 mg
EUR 312

mAb rat anti-mouse IL-4

CT337 0.5 mg
EUR 312

Human FibrOut 4, for brain, neural

4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural

4-21553 5 x 1 ml Ask for price

Recombinant Human 4-1BB Receptor Protein

PROTQ07011-4 20ug
EUR 380.4
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein

PROTP02776-4 20ug
EUR 380.4
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Feline IL-1 beta Recombinant Protein

R00101-4 5ug/vial
EUR 310.8
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Feline IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Feline IL-1 alpha Recombinant Protein

R01144-4 5ug/vial
EUR 310.8
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Feline IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.

rHu IL-4

AK8329-0005 5µg Ask for price

rHu IL-4

AK8329-0020 20µg Ask for price

rHu IL-4

AK8329-0100 100µg Ask for price

rHu IL-4

AK8329-1000 1mg Ask for price

IL-4 Antibody

5137-200
EUR 444

IL-4 Antibody

5137-30T
EUR 175.2

IL-4 antigen

E6IE600107 20ug
EUR 411.6

IL-4 antigen

E6L00107 20ug
EUR 458.4

IL-4 antibody

PAab09861 100 ug
EUR 463.2

IL-4 Antibody

R30605 100 ug
EUR 419

IL-4 Antibody

R30841 100 ug
EUR 419

IL-4 Antibody

RQ4162 100 ug
EUR 419

IL-4 Antibody

RQ5106 100ul
EUR 419

IL-4 Antibody

V7884-100UG 100 ug
EUR 499
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

IL-4 Antibody

V7884-20UG 20 ug
EUR 219
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

IL-4 Antibody

V7884SAF-100UG 100 ug
EUR 499
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

IL-4 Antibody

V8351-100UG 100 ug
EUR 499
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

IL-4 Antibody

V8351-20UG 20 ug
EUR 219
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

IL-4 Antibody

V8351SAF-100UG 100 ug
EUR 499
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

IL-4 Antibody

F49086-0.08ML 0.08 ml
EUR 165

IL-4 Antibody

F49086-0.4ML 0.4 ml
EUR 379

Human Interleukin 4, IL-4 ELISA KIT

CSB-E04633h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 4, IL-4 ELISA KIT

1-CSB-E04633h
  • EUR 600.00
  • EUR 4082.40
  • EUR 2184.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 4,IL-4 ELISA KIT

CN-03206H1 96T
EUR 520.8

Human Interleukin 4,IL-4 ELISA KIT

CN-03206H2 48T
EUR 340.8

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0010 10ug
EUR 780

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0030 30ug
EUR 1356

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