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Antibody-protein binding and conformational changes

Antibody-protein binding and conformational changes

chipab

Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to engineer a greater effector response

Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses.

However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.

On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction. The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.

Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. At school (B2), we discovered adjustments in the identical loop area with out the general distortion.

At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.

Consequently, structural evaluation of antibodies is essential for therapeutic improvement. Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.

 

chipab
chipab

anti-CD16 (Q32)

LF-MA20383 100 ug
EUR 354
Description: Mouse monoclonal to CD16

Anti-CD16 antibody

STJ16100025 100 µg
EUR 406

Anti-CD16 antibody

STJ16100111 0.5 mL
EUR 480

Anti-CD16 antibody

STJ16100112 0.5 mL
EUR 541

Anti-CD16 antibody

STJ16100113 0.5 mL
EUR 609

Anti-CD16 antibody

STJ16100960 100 tests
EUR 524

Anti-CD16 antibody

STJ16101087 100 µg
EUR 354

Anti-CD16 antibody

STJ16101088 100 µg
EUR 354

Anti-CD16 antibody

STJ180039 0.1 ml
EUR 233

Anti-CD16 antibody

STJ180346 0.1 ml
EUR 221

Anti-CD16 antibody

STJ96992 200 µl
EUR 197
Description: CD16 is a protein encoded by the FCGR3A gene which is approximately 29 kDa. CD16 is localised to the cell membrane. It is involved in the immune response role of DAP12 receptors in NK cells, regulation of actin dynamics for phagocytic cup formation and the role of phospholipids in phagocytosis. It is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from circulation, as well as other antibody-dependent responses. CD16 is expressed on natural killer cells, macrophages, a subpopulation of T-cells, immature thymocytes and placental trophoblasts. Mutations in the FCGR3A gene may result in an immunodeficiency. STJ96992 was developed from clone Q32 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous CD16 protein.

Anti-CD16 antibody

STJ98738 200 µl
EUR 197
Description: Rabbit polyclonal to CD16.

Anti-CD16 (2B11)

YF-MA12975 50 ug
EUR 363
Description: Mouse monoclonal to CD16

Anti-CD16 (2B11)

YF-MA12976 200 ul
EUR 363
Description: Mouse monoclonal to CD16

Anti-Hu CD16 Purified

11-214-C025 0.025 mg
EUR 99

Anti-Hu CD16 Purified

11-214-C100 0.1 mg
EUR 158

Anti-Hu CD16 Purified

11-382-C025 0.025 mg
EUR 99

Anti-Hu CD16 Purified

11-382-C100 0.1 mg
EUR 158

Anti-Hu CD16 Purified

11-399-C025 0.025 mg
EUR 99

Anti-Hu CD16 Purified

11-399-C100 0.1 mg
EUR 158

Anti-Hu CD16 Purified

11-646-C025 0.025 mg
EUR 99

Anti-Hu CD16 Purified

11-646-C100 0.1 mg
EUR 158

Anti-Hu CD16 APC

1A-646-T025 25 tests
EUR 140

Anti-Hu CD16 APC

1A-646-T100 100 tests
EUR 240

Anti-Hu CD16 Biotin

1B-214-C025 0.025 mg
EUR 122

Anti-Hu CD16 Biotin

1B-214-C100 0.1 mg
EUR 204

Anti-Hu CD16 Biotin

1B-646-C025 0.025 mg
EUR 122

Anti-Hu CD16 Biotin

1B-646-C100 0.1 mg
EUR 204

Anti-Hu CD16 FITC

1F-214-T025 25 tests
EUR 122

Anti-Hu CD16 FITC

1F-214-T100 100 tests
EUR 204

Anti-Hu CD16 FITC

1F-399-T025 25 tests
EUR 122

Anti-Hu CD16 FITC

1F-399-T100 100 tests
EUR 204

Anti-Hu CD16 FITC

1F-646-T025 25 tests
EUR 122

Anti-Hu CD16 FITC

1F-646-T100 100 tests
EUR 204

Anti-Hu CD16 PE

1P-214-T025 25 tests
EUR 140

Anti-Hu CD16 PE

1P-214-T100 100 tests
EUR 240

Anti-Hu CD16 PE

1P-399-T025 25 tests
EUR 140

Anti-Hu CD16 PE

1P-399-T100 100 tests
EUR 240

Anti-Hu CD16 PE

1P-646-T025 25 tests
EUR 140

Anti-Hu CD16 PE

1P-646-T100 100 tests
EUR 240

anti-CD16 monoclonal antibody

063-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD16 monoclonal antibody

anti-CD16 monoclonal antibody

063-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-CD16 monoclonal antibody

Anti-CD16/FCGR3A Antibody

A01408-1 100ug/vial
EUR 294

Anti-CD16+CD32 antibody

MO16A(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16A(V25) 25 ug
EUR 50

Anti-CD16+CD32 antibody

MO16B(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16B(V25) 25 ug
EUR 50

Anti-CD16+CD32 antibody

MO16CFB(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16CFB(V25) 25 ug
EUR 50

Anti-CD16+CD32 antibody

MO16F(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16F(V25) 25 ug
EUR 50

Anti-CD16+CD32 antibody

MO16F(V500) 500 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PE(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PE(V25) 25 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PP(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PP(V25) 25 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PP5.5(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PP5.5(V25) 25 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PU(V100) 100 ug
EUR 50

Anti-CD16+CD32 antibody

MO16PU(V500) 500 ug
EUR 50

Anti-Hu CD16 PerCP

PC-646-T025 25 tests
EUR 140

Anti-Hu CD16 PerCP

PC-646-T100 100 tests
EUR 240

Mouse Anti Human Cd16 Monoclonal Antibody

CABT-45628MH 0.1 mg
EUR 533

Mouse Anti Human Cd16 Monoclonal Antibody

CABT-45641MH 0.2 mg
EUR 767

Rat Anti Human Cd16 Monoclonal Antibody

CABT-45643RH 0.2 mg
EUR 741

Mouse Monoclonal Anti-Human CD16, Unlabeled

CD16UL-100 100 ug
EUR 408

CD16

16A2-100T 100 test
EUR 427

CD16

16B2-01MG 100 test
EUR 284

CD16

16CFB2-100T 100 test
EUR 388

CD16

16F-100T 100 test
EUR 297

CD16

16F2-100T 100 test
EUR 310

CD16

16PE2-100T 100 test
EUR 349

CD16

16PP2-100T 100 test
EUR 570

CD16

16PU-01MG 0,1 mg
EUR 219

CD16

16PU2-01MG 0,1 mg
EUR 219

Anti-Ms CD16/CD32 Purified

11-141-C025 0.025 mg
EUR 76

Anti-Ms CD16/CD32 Purified

11-141-C100 0.1 mg
EUR 113

Anti-Ms CD16/CD32 FITC

1F-141-C025 0.025 mg
EUR 86

Anti-Ms CD16/CD32 FITC

1F-141-C100 0.1 mg
EUR 131

Anti-Ms CD16/CD32 PE

1P-141-C025 0.025 mg
EUR 90

Anti-Ms CD16/CD32 PE

1P-141-C100 0.1 mg
EUR 140

Anti-Hu CD16 Alexa Fluor488

A4-646-T025 25 tests
EUR 154

Anti-Hu CD16 Alexa Fluor647

A6-646-T025 25 tests
EUR 154

Anti-Hu CD16 Alexa Fluor647

A6-646-T100 100 tests
EUR 269

Anti-Hu CD16 Alexa Fluor700

A7-646-T025 25 tests
EUR 154

Anti-Hu CD16 Alexa Fluor700

A7-646-T100 100 tests
EUR 269

Anti-Hu CD16 Pacific Blue

PB-646-T025 25 tests
EUR 154

Anti-Hu CD16 Pacific Blue

PB-646-T100 100 tests
EUR 269

Anti-Hu CD16 Pacific Orange

PO-646-T025 25 tests
EUR 154

Anti-Hu CD16 Pacific Orange

PO-646-T100 100 tests
EUR 269

 

Antibody-enhanced hepatitis E virus nanofiltration in the course of the manufacture of human immunoglobulin

 

Background: Circulation of hepatitis E virus (HEV) in areas the place plasma is sourced for the manufacture of plasma-derived medicinal merchandise (PDMPs) has prompted verification of HEV clearance.
HEV exists as quasi lipid-enveloped (LE) and non-lipid-enveloped (NLE) types, which could be of relevance for HEV clearance from manufacturing processes of antibody-containing PDMPs with solvent/detergent (S/D) remedy upstream of additional clearance steps.
Research design and strategies: Presence of various HEV particles in shares utilized in clearance research was investigated, with nanofilters graded across the assumed HEV particle sizes and by gradient centrifugation.
HEV elimination by 35-nm nanofiltration was investigated within the presence or absence of HEV antibodies, in buffer in addition to in immunoglobulin (IG) manufacturing course of intermediates.
Outcomes: HEV particles in line with LE, NLE, and an “intermediate” (IM) phenotype, obtained after S/D remedy, had been seen in numerous HEV shares. Within the absence of HEV antibodies, log discount elements (LRFs) of 4.Zero and a couple of.5 had been obtained by 35-nm nanofiltration of LE and IM HEV, constant with the bigger and smaller sizes of those phenotypes.
Addition of HEV antibodies enhanced IM HEV elimination round 1000-fold (LRF, 5.6). Efficient (LRF, >4.eight and >4.0) HEV elimination was obtained for the nanofiltration processing step for IG intermediates with various HEV antibody content material.
Conclusion: HEV spikes utilized in clearance research must be rigorously chosen, as variations in physicochemical properties may have an effect on HEV clearance.
Antibody-mediated enhancement of HEV nanofiltration was demonstrated in IG course of intermediates even at low HEV antibody focus, illustrating the robustness of this manufacturing step.
Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to
engineer a greater effector response.
Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses. However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.
On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction.
The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.
Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. I
n class (B2), we discovered adjustments in the identical loop area with out the general distortion. At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.
Consequently, structural evaluation of antibodies is essential for therapeutic improvement.
Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.
Anti-human IL-4 antibody
STJ15100045 250 µg
EUR 336
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.
Anti-human IL-4 antibody
STJ15100046 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.
anti- IL-4 antibody
FNab09861 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500 - 1:1000
  • Immunogen: interleukin 4
  • Uniprot ID: P05112
  • Gene ID: 3565
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against IL-4
anti- IL-4 antibody
FNab04278 100µg
EUR 585
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:100
  • Immunogen: interleukin 4
  • Uniprot ID: P05112
  • Gene ID: 3565
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against IL-4
anti- IL-4 antibody
FNab04279 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: interleukin 4
  • Uniprot ID: P05112
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against IL-4
anti- IL-4 antibody
LSMab09861 100 ug
EUR 386
Anti-IL-4 antibody
PAab04278 100 ug
EUR 412
Anti-IL-4 antibody
STJ93699 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4.
Anti-IL-4 antibody
STJ93700 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4.
Anti-IL-4 antibody
STJ96510 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4.
mAb mouse anti-human IL-4
CT253 0.5 mg
EUR 260
Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349
Recombinant Human IL-2 Protein
PROTP60568-4 50ug
EUR 317
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.
Recombinant Human IL-17F Protein
PROTQ96PD4-4 25ug
EUR 317
Description: IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant human IL-17F is a disulfide-linked homodimer of 30.1 kDa, consisting of two 133 amino acid residue chains.
Recombinant Human IL-6 Protein
PROTP05231-4 20ug
EUR 317
Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
Recombinant Human IL-3 Protein
PROTP08700-4 10ug
EUR 317
Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.
Anti-mouse IL-4 antibody
STJ15100035 250 µg
EUR 336
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.
Anti-mouse IL-4 antibody
STJ15100036 500 µg
EUR 527
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.
Anti-mouse IL-4 antibody
STJ15100037 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.
Anti-IL-4 alpha antibody
STJ93702 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4Ralpha.
Anti-IL-4 alpha antibody
STJ93703 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4Ralpha.
Anti-IL-4 alpha antibody
STJ97665 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4Ralpha.
Recombinant Human IL-12 p80 Protein
PROTP29460-4 10ug
EUR 317
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.
Recombinant Human IL-13 Variant Protein
PROTP35225-4 10ug
EUR 317
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.
Human Interleukin-4 (IL-4)
1-CSB-EP011659HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 31 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli
IL-4, Interleukin-4, human
RC212-15 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines
IL-4
E13-015-1 10μg
EUR 161
IL-4
E13-015-2 50μg
EUR 505
IL-4
E21-050 10ug
EUR 343
IL-4
E21-D03 10ug
EUR 343
IL-4
E21-K15 10ug
EUR 343
IL-4
MO15071 500 ug
EUR 910
pAb rabbit anti-human IL-4 receptor
CT248 0.5 mg
EUR 184
Recombinant Human IL-16 (129 a.a.) Protein
PROTQ14005-4 10ug
EUR 317
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues.
mAb mouse anti-rat IL-4
CT028 0.5 mg
EUR 260
mAb mouse anti-rat IL-4
CT029 0.5 mg
EUR 260
pAb rabbit anti-rat IL-4
CT058 0.5 mg
EUR 184
mAb mouse anti-monkey IL-4
CT103 0.5 mg
EUR 260
mAb rat anti-mouse IL-4
CT324 0.5 mg
EUR 260
mAb rat anti-mouse IL-4
CT337 0.5 mg
EUR 260
IL-4, human recombinant
4137-10
EUR 278
IL-4, human recombinant
4137-1000
EUR 3704
IL-4, human recombinant
4137-50
EUR 697
Human IL-4 Protein
abx060798-20ug 20 ug
EUR 467
  • Shipped within 5-10 working days.
rec IL-4 (human)
H-9630.0002 2.0µg
EUR 261
rec IL-4 (human)
H-9630.0010 10.0µg
EUR 950
Recombinant Human IL-4
P0052 100ug
EUR 522.36
  • Formulation: pH7.4, Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose
  • Reconstitution: Sterile distilled water
  • Purity: Greater than 95% by SDS-PAGE gel analyses
  • Uniprot ID: P05112
Description: Recombinant Human protein for IL-4
Recombinant Human IL-4
SJB02-03 10µg/vial
EUR 285
Recombinant Human IL-4
SJB02-05 100µg/vial
EUR 720
Recombinant Human IL-4
SJB02-06 30µg/vial
EUR 430
Interleukin-4/IL-4
E21-K74 10ug
EUR 343
Recombinant Human IL-8 (72 a.a.) (CXCL8) Protein
PROTP10145-4 25ug
EUR 317
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.
Human Interleukin-4 (IL-4) Antibody
32184-05111 150 ug
EUR 261
Swine IL-10 Recombinant Protein
R00021-4 5ug/vial
EUR 259
Description: IL-10 is an anti-inflammatory cytokine and a member of the IL-10 family of cytokines, which have indispensable functions in many infectious and inflammatory diseases. Swine IL-10 Recombinant Protein is purified interleukin-10 produced in yeast.
Mouse IL-13 Recombinant Protein
R00077-4 5ug/vial
EUR 259
Description: IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Mouse IL-13 Recombinant Protein is purified interleukin-13 produced in yeast.
Feline IL-6 Recombinant Protein
R00102-4 5ug/vial
EUR 259
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Feline IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.
Feline IL-2 Recombinant Protein
R00387-4 5ug/vial
EUR 259
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Feline IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.
Mouse IL-17A Recombinant Protein
R00421-4 5ug/vial
EUR 259
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Mouse IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.
Dolphin IL-8 Recombinant Protein
R00423-4 5ug/vial
EUR 259
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Dolphin IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.
Swine IL-21 Recombinant Protein
R00459-4 5ug/vial
EUR 259
Description: The cytokine interleukin-21 (IL-21) regulates the proliferation and differentiation of T and B lymphocytes, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. Swine IL-21 Recombinant Protein is purified interleukin-21 produced in yeast.
Equine IL-1ra Recombinant Protein
R00651-4 5ug/vial
EUR 259
Description: Interleukin-1 Receptor Antagonist Protein (IL-1F3, IL-1ra) belongs to the IL-1 family of cytokines, whose members play key roles in the development and regulation of inflammation. IL-1 receptor antagonist (IL-1ra; IL-1F3) reduces inflammation by blocking the binding of the agonist receptor ligands. Equine IL-1 Receptor Antagonist Recombinant Protein is purified interleukin-1 receptor antagonist protein (IL-1F3, IL-1ra) produced in yeast.
IL-7 Interleukin-7 Human Recombinant Protein, His Tag
PROTP13232-4 Regular: 10ug
EUR 317
Description: IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. ;The IL-7 His-Tag protein is purified by proprietary chromatographic techniques.
Feline IL-1 alpha Recombinant Protein
R01144-4 5ug/vial
EUR 259
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Feline IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.
Feline IL-1 beta Recombinant Protein
R00101-4 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Feline IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.
IL-4 Antibody
5137-200
EUR 370
IL-4 Antibody
5137-30T
EUR 146
IL-4 antigen
E6IE600107 20ug
EUR 343
IL-4 antigen
E6L00107 20ug
EUR 382
rHu IL-4
AK8329-0005 5µg Ask for price
rHu IL-4
AK8329-0020 20µg Ask for price
rHu IL-4
AK8329-0100 100µg Ask for price
rHu IL-4
AK8329-1000 1mg Ask for price
IL-4 antibody
PAab09861 100 ug
EUR 386
Human FibrOut 4, for brain, neural
4-21552 1 ml Ask for price
Human FibrOut 4, for brain, neural
4-21553 5 x 1 ml Ask for price
Recombinant Human 4-1BB Receptor Protein
PROTQ07011-4 20ug
EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.
Recombinant Human PF-4 (CXCL4) Protein
PROTP02776-4 20ug
EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.
Anti-IL-4 Antibody [11B11], Unconjugated-100ug
QAB81-100ug 100ug
EUR 149
Anti-IL-4 Antibody [11B11], Unconjugated-500ug
QAB81-500ug 500ug
EUR 233
Anti-IL-4 Antibody [11B11], APC-100ug
QAB81-APC-100ug 100ug
EUR 276
Anti-IL-4 Antibody [11B11], APC-25ug
QAB81-APC-25ug 25ug
EUR 131
Anti-IL-4 Antibody [11B11], PE-100ug
QAB81-PE-100ug 100ug
EUR 259
Anti-IL-4 Antibody [11B11], PE-25ug
QAB81-PE-25ug 25ug
EUR 141
Anti-Phospho-IL-4 alpha (Y497) antibody
STJ90720 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-IL-4Ralpha (Y497).
Interleukin 4 (IL-4) Antibody
abx234279-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.
IL-4, Interleukin-4, monkey
RC222-15 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines
IL-4, Interleukin-4, rat
RC252-15 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines
Human Interleukin 4,IL-4 ELISA KIT
201-12-0093 96 tests
EUR 440
  • This Interleukin 4 ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
Human Interleukin 4, IL-4 ELISA KIT
CSB-E04633h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Human Interleukin 4, IL-4 ELISA KIT
1-CSB-E04633h
  • EUR 500.00
  • EUR 3402.00
  • EUR 1820.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Human Interleukin 4 (IL-4) CLIA Kit
abx195899-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Human IL-4(Interleukin 4) ELISA Kit
EH0199 96T
EUR 476.25
  • Detection range: 31.25-2000 pg/ml
  • Uniprot ID: P05112
  • Alias: IL-4(Interleukin 4)/IL4/BCGF-1/BCGF1/BSF-1/BSF1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

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