Best Supplier of Molecular Products

Antibody-protein binding and conformational changes

Antibody-protein binding and conformational changes

chipab

Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to engineer a greater effector response

Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses.

However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.

On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction. The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.

Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. At school (B2), we discovered adjustments in the identical loop area with out the general distortion.

At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.

Consequently, structural evaluation of antibodies is essential for therapeutic improvement. Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.

 

chipab
chipab

anti- CD16 antibody

FNab10139 100µg
EUR 702
Description: Antibody raised against CD16

Anti-Hu CD16 PE

1P-214-T025 25 tests
EUR 168

Anti-Hu CD16 PE

1P-214-T100 100 tests
EUR 288

Anti-Hu CD16 PE

1P-399-T025 25 tests
EUR 168

Anti-Hu CD16 PE

1P-399-T100 100 tests
EUR 288

Anti-Hu CD16 PE

1P-646-T025 25 tests
EUR 168

Anti-Hu CD16 PE

1P-646-T100 100 tests
EUR 288

Anti-CD16+CD32 antibody

MO16A(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16A(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V500) 500 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V500) 500 ug
EUR 60

Anti-Hu CD16 APC

1A-646-T025 25 tests
EUR 168

Anti-Hu CD16 APC

1A-646-T100 100 tests
EUR 288

Anti-Hu CD16 FITC

1F-214-T025 25 tests
EUR 146.4

Anti-Hu CD16 FITC

1F-214-T100 100 tests
EUR 244.8

Anti-Hu CD16 FITC

1F-399-T025 25 tests
EUR 146.4

Anti-Hu CD16 FITC

1F-399-T100 100 tests
EUR 244.8

Anti-Hu CD16 FITC

1F-646-T025 25 tests
EUR 146.4

Anti-Hu CD16 FITC

1F-646-T100 100 tests
EUR 244.8

Anti-Hu CD16 PerCP

PC-646-T025 25 tests
EUR 168

Anti-Hu CD16 PerCP

PC-646-T100 100 tests
EUR 288

Anti-Hu CD16 Biotin

1B-214-C025 0.025 mg
EUR 146.4

Anti-Hu CD16 Biotin

1B-214-C100 0.1 mg
EUR 244.8

Anti-Hu CD16 Biotin

1B-646-C025 0.025 mg
EUR 146.4

Anti-Hu CD16 Biotin

1B-646-C100 0.1 mg
EUR 244.8

Anti-Hu CD16 Purified

11-214-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-214-C100 0.1 mg
EUR 189.6

Anti-Hu CD16 Purified

11-382-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-382-C100 0.1 mg
EUR 189.6

Anti-Hu CD16 Purified

11-399-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-399-C100 0.1 mg
EUR 189.6

Anti-Hu CD16 Purified

11-646-C025 0.025 mg
EUR 118.8

Anti-Hu CD16 Purified

11-646-C100 0.1 mg
EUR 189.6

PE Anti-human CD16 Antibody *3G8*

101611L0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD16 Antibody *3G8*

101611L1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD16 Antibody *3G8*

101611L2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD16 Antibody *3G8*

101611L0-25tests 25 tests
EUR 179
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PE Anti-human CD16 Antibody *3G8*

101611L1-100tests 100 tests
EUR 505
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PE Anti-human CD16 Antibody *3G8*

101611L2-500tests 500 tests
EUR 1887
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

APC Anti-human CD16 Antibody *3G8*

101611C0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD16 Antibody *3G8*

101611C1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD16 Antibody *3G8*

101611C2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD16 Antibody *3G8*

101611C0-25tests 25 tests
EUR 179
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

APC Anti-human CD16 Antibody *3G8*

101611C1-100tests 100 tests
EUR 505
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

APC Anti-human CD16 Antibody *3G8*

101611C2-500tests 500 tests
EUR 1887
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PE Anti-human CD16 Antibody *HI16a*

101601L0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD16 Antibody *HI16a*

101601L1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD16 Antibody *HI16a*

101601L2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD16 Antibody *3G8*

101611H0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD16 Antibody *3G8*

101611H1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD16 Antibody *HI16a*

101601L0-25tests 25 tests
EUR 179
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

PE Anti-human CD16 Antibody *HI16a*

101601L1-100tests 100 tests
EUR 505
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

PE Anti-human CD16 Antibody *HI16a*

101601L2-500tests 500 tests
EUR 1887
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

FITC Anti-human CD16 Antibody *3G8*

101611H0-100tests 100 tests
EUR 245
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

FITC Anti-human CD16 Antibody *3G8*

101611H1-500tests 500 tests
EUR 918
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

APC Anti-human CD16 Antibody *HI16a*

101601C0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD16 Antibody *HI16a*

101601C1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD16 Antibody *HI16a*

101601C2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

TRITC Anti-human CD16 Antibody *3G8*

101611I0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

TRITC Anti-human CD16 Antibody *3G8*

101611I1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD16 Antibody *3G8*

101611T0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD16 Antibody *3G8*

101611T1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD16 Antibody *3G8*

101611T2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD16 Antibody *HI16a*

101601C0-25tests 25 tests
EUR 179
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

APC Anti-human CD16 Antibody *HI16a*

101601C1-100tests 100 tests
EUR 505
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

APC Anti-human CD16 Antibody *HI16a*

101601C2-500tests 500 tests
EUR 1887
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

TRITC Anti-human CD16 Antibody *3G8*

101611I0-100tests 100 tests
EUR 245
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

TRITC Anti-human CD16 Antibody *3G8*

101611I1-500tests 500 tests
EUR 918
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PerCP Anti-human CD16 Antibody *3G8*

101611T0-25tests 25 tests
EUR 179
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PerCP Anti-human CD16 Antibody *3G8*

101611T1-100tests 100 tests
EUR 505
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

PerCP Anti-human CD16 Antibody *3G8*

101611T2-500tests 500 tests
EUR 1887
Description: The 3G8 monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane protein typically found on the surface of macrophages, natural killer cells, dendritic cells, monocytes and neutrophils.

FITC Anti-human CD16 Antibody *HI16a*

101601H0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD16 Antibody *HI16a*

101601H1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD16 Antibody *HI16a*

101601H0-100tests 100 tests
EUR 245
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

FITC Anti-human CD16 Antibody *HI16a*

101601H1-500tests 500 tests
EUR 918
Description: The HI16a monoclonal antibody recognizes human CD16a, a 50 - 65 kD transmembrane glycoprotein often located on the surface of neutrophils, natural killer cells and macrophages.

TRITC Anti-human CD16 Antibody *HI16a*

101601I0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

TRITC Anti-human CD16 Antibody *HI16a*

101601I1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

 

Antibody-enhanced hepatitis E virus nanofiltration in the course of the manufacture of human immunoglobulin

 

Background: Circulation of hepatitis E virus (HEV) in areas the place plasma is sourced for the manufacture of plasma-derived medicinal merchandise (PDMPs) has prompted verification of HEV clearance.
HEV exists as quasi lipid-enveloped (LE) and non-lipid-enveloped (NLE) types, which could be of relevance for HEV clearance from manufacturing processes of antibody-containing PDMPs with solvent/detergent (S/D) remedy upstream of additional clearance steps.
Research design and strategies: Presence of various HEV particles in shares utilized in clearance research was investigated, with nanofilters graded across the assumed HEV particle sizes and by gradient centrifugation.
HEV elimination by 35-nm nanofiltration was investigated within the presence or absence of HEV antibodies, in buffer in addition to in immunoglobulin (IG) manufacturing course of intermediates.
Outcomes: HEV particles in line with LE, NLE, and an “intermediate” (IM) phenotype, obtained after S/D remedy, had been seen in numerous HEV shares. Within the absence of HEV antibodies, log discount elements (LRFs) of 4.Zero and a couple of.5 had been obtained by 35-nm nanofiltration of LE and IM HEV, constant with the bigger and smaller sizes of those phenotypes.
Addition of HEV antibodies enhanced IM HEV elimination round 1000-fold (LRF, 5.6). Efficient (LRF, >4.eight and >4.0) HEV elimination was obtained for the nanofiltration processing step for IG intermediates with various HEV antibody content material.
Conclusion: HEV spikes utilized in clearance research must be rigorously chosen, as variations in physicochemical properties may have an effect on HEV clearance.
Antibody-mediated enhancement of HEV nanofiltration was demonstrated in IG course of intermediates even at low HEV antibody focus, illustrating the robustness of this manufacturing step.
Antibody-protein binding and conformational adjustments: figuring out allosteric signalling pathways to
engineer a greater effector response.
Quite a few monoclonal antibodies have been developed efficiently for the remedy of varied illnesses. However, the event of biotherapeutic antibodies is advanced, costly, and time-consuming, and to facilitate this course of, cautious structural evaluation past the antibody binding web site is required to develop a extra efficacious antibody.
On this work, we centered on protein antigens, since they induce the most important antibody adjustments, and supply attention-grabbing circumstances to check and distinction.
The constructions of 15 anti-protein antibodies had been analysed to check the antigen-bound/unbound types.
Surprisingly, three totally different courses of binding-induced adjustments had been recognized. At school (B1), the antigen binding fragment distorted considerably, and we discovered adjustments within the loop area of the heavy chain’s fixed area; this corresponds nicely with anticipated allosteric actions. I
n class (B2), we discovered adjustments in the identical loop area with out the general distortion. At school (B3), these adjustments didn’t current, and solely native adjustments on the complementarity figuring out areas had been discovered.
Consequently, structural evaluation of antibodies is essential for therapeutic improvement.
Cautious analysis of allosteric actions have to be undertaken to develop higher effector responses, particularly in the course of the transformation of those antibodies from small fragments on the discovery stage to full antibodies on the subsequent improvement levels.

anti- IL-4 antibody

LSMab09861 100 ug
EUR 463.2

Anti-IL-4 antibody

PAab04278 100 ug
EUR 494.4

Anti-IL-4 antibody

STJ96510 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93699 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93700 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Human Interleukin-4 (IL-4)

1-CSB-EP011659HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

IL-4, Interleukin-4, human

RC212-15 5ug
EUR 125.26

mAb mouse anti-human IL-4

CT253 0.5 mg
EUR 312

rec IL-4 (human)

H-9630.0002 2.0µg
EUR 313.2

rec IL-4 (human)

H-9630.0010 10.0µg
EUR 1140

Human IL-4 Protein

abx060798-20ug 20 ug
EUR 560.4

Anti-mouse IL-4 antibody

STJ15100035 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-mouse IL-4 antibody

STJ15100036 500 µg
EUR 632.4
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.

Anti-mouse IL-4 antibody

STJ15100037 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-IL-4 alpha antibody

STJ97665 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody

STJ93702 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody

STJ93703 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

IL-4, human recombinant

4137-10 each
EUR 333.6

IL-4, human recombinant

4137-1000 each
EUR 4444.8

IL-4, human recombinant

4137-50 each
EUR 836.4

Recombinant Human IL-4

P0052 100ug
EUR 626.83
Description: Recombinant Human protein for IL-4

Recombinant Human IL-4

SJB02-03 10µg/vial
EUR 342

Recombinant Human IL-4

SJB02-05 100µg/vial
EUR 864

Recombinant Human IL-4

SJB02-06 30µg/vial
EUR 516

Recombinant Human IL-4

HEILP-0401 5ug Ask for price

Human IL-4 ELISA antibody pair

CT742-10 10-plate
EUR 656.4

Human IL-4 ELISA antibody pair

CT742-20 20-plate
EUR 1118.4

Human Interleukin-4 (IL-4) Antibody (Biotin Conjugate)

32184-05121 150 ug
EUR 442.8

Human IL-4 ELISPOT antibody pair

CT642-10 10-plate
EUR 633.6

Human IL-4 ELISPOT antibody pair

CT642-20 20-plate
EUR 1107.6

pAb rabbit anti-human IL-4 receptor

CT248 0.5 mg
EUR 220.8

Human High Sensitive Interleukin IL-4,IL-4 ELISA Kit

YLA4123HU-48T 48T
EUR 435

Human High Sensitive Interleukin IL-4,IL-4 ELISA Kit

YLA4123HU-96T 96T
EUR 562.5

Recombinant Human Interleukin-4/IL-4 (Human Cells)

CX03-10ug 10ug
EUR 175.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-4/IL-4 (Human Cells)

CX03-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-4/IL-4 (Human Cells)

CX03-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-4/IL-4 (Human Cells)

CX03-50ug 50ug
EUR 406.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

human IL-4, His tag

E410A04-100 100μg
EUR 1152

Human Interleukin 4 (IL-4) CLIA Kit

abx195899-96tests 96 tests
EUR 990

Human IL-4 ELISA kit

CT203A 5-plate
EUR 554.4

Human IL-4 ELISA kit

LF-EK50141 1×96T
EUR 777.6

IL-4 ELISA KIT|Human

EF000163 96 Tests
EUR 826.8

IL-4 (Human) ELISA Kit

K4164-100 each
EUR 874.8

Human IL-4 ELISA Kit

RK00003 96 Tests
EUR 625.2

Human Interleukin 4,IL-4 ELISA KIT

201-12-0093 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Interleukin 4, IL-4 ELISA KIT

CSB-E04633h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 4, IL-4 ELISA KIT

1-CSB-E04633h
  • EUR 600.00
  • EUR 4082.40
  • EUR 2184.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 4,IL-4 ELISA KIT

CN-03206H1 96T
EUR 520.8

Human Interleukin 4,IL-4 ELISA KIT

CN-03206H2 48T
EUR 340.8

Human Interleukin 4(IL-4)ELISA Kit

GA-E0132HM-48T 48T
EUR 346.8

Human Interleukin 4(IL-4)ELISA Kit

GA-E0132HM-96T 96T
EUR 559.2

Human IL-4(Interleukin 4) ELISA Kit

EH0199 96T
EUR 571.5
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Human Interleukin 4(IL-4)ELISA Kit

QY-E04267 96T
EUR 433.2

Human Interleukin 4,IL-4 ELISA Kit

YLA1519HU-48T 48T
EUR 435

Human Interleukin 4,IL-4 ELISA Kit

YLA1519HU-96T 96T
EUR 562.5

Human Interleukin-4 (IL-4) ELISA Kit

LF-EK60025 1×96T
EUR 948

Human IL-4 ELISPOT kit

CT232-PB2 2-plate
EUR 498

Human IL-4 ELISPOT kit

CT232-PB5 5-plate
EUR 681.6

Human IL-4 ELISPOT kit

CT232-PR2 2-plate
EUR 498

Human IL-4 ELISPOT kit

CT232-PR5 5-plate
EUR 667.2

Human IL-4 ELISPOT kit

CT232-T2 2-plate
EUR 432

Human IL-4 ELISPOT kit

CT232-T5 5-plate
EUR 694.8

IL-4 (CHO-expressed), Human

HY-P7042 50ug
EUR 666

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0010 10ug
EUR 780

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0030 30ug
EUR 1356

Recombinant Human Interleukin-4 (rHu IL-4)

AK9839-0100 100ug
EUR 2040

GMP Recombinant Human Interleukin-4 (IL-4)

GMPhuIL-4-50ug 50ug
EUR 528

Recombinant Human IL-4 Protein

PROTP05112-5 15ug
EUR 380.4
Description: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.

Recombinant Human IL-4 Protein

RP00995 5 μg
EUR 163.2

Human IL-4 Recombinant Protein

R00230-5 5ug/vial
EUR 310.8
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Human IL-4 Recombinant Protein is purified interleukin-4 produced in yeast.

Human Interleukin-4 (IL-4) AssayLite Antibody (RPE Conjugate)

32184-05151 150 ug
EUR 513.6

Human Interleukin-4 (IL-4) AssayLite Antibody (APC Conjugate)

32184-05161 150 ug
EUR 513.6

IL-4 Interleukin-4 Human Recombinant Protein

PROTP05112-1 Regular: 20ug
EUR 380.4
Description: Interleukin-4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15kDa. ;The IL-4 is purified by proprietary chromatographic techniques.

Human Interleukin-4 (IL-4) AssayLite Antibody (FITC Conjugate)

32184-05141 150 ug
EUR 513.6

Human CellExp? IL-4, Human Recombinant

6463-10 each
EUR 477.6

Human CellExp? IL-4, Human Recombinant

6463-50 each
EUR 1677.6

Human Interleukin-4 (IL-4) AssayLite Antibody (PerCP Conjugate)

32184-05171 150 ug
EUR 565.2

mAb mouse anti-rat IL-4

CT028 0.5 mg
EUR 312

mAb mouse anti-rat IL-4

CT029 0.5 mg
EUR 312

mAb rat anti-mouse IL-4

CT324 0.5 mg
EUR 312

mAb rat anti-mouse IL-4

CT337 0.5 mg
EUR 312

pAb rabbit anti-rat IL-4

CT058 0.5 mg
EUR 220.8

mAb mouse anti-monkey IL-4

CT103 0.5 mg
EUR 312

IL-4 antigen

E6IE600107 20ug
EUR 411.6

IL-4 antigen

E6L00107 20ug
EUR 458.4

IL-4 Antibody

5137-200 each
EUR 444

IL-4 Antibody

5137-30T each
EUR 175.2

IL-4 Antibody

F49086-0.08ML 0.08 ml
EUR 140.25
Description: IL4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome.

IL-4 Antibody

F49086-0.4ML 0.4 ml
EUR 322.15
Description: IL4 is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome.

IL-4 antibody

PAab09861 100 ug
EUR 463.2

IL-4 Antibody

RQ4162 100 ug
EUR 356.15
Description: Interleukin-4 (IL-4), also known as a B-cell stimulatory factor1 (BSF1), is an immunomodulatory cytokine, which can inhibit the growth of tumour cells.1 The human cDNA contains a single open reading frame encoding a protein of 153 amino acids, including a putative signal peptide. IL-4 may act as an autocrine growth factor in pancreatic cancer cells and also give rise to the possibility that cancer-derived IL-4 may suppress cancer-directed immunosurveillance in vivo in addition to its growth-promoting effects, thereby facilitating pancreatic tumor growth and metastasis. The mouse and human genes and their protein products show structural and functional similarities.

IL-4 Antibody

R30605 100 ug
EUR 356.15
Description: Interleukin-4, also knowns as a B-cell stimulatory factor 1 (BSF1), is an immunomodulatory cytokine, which can inhibit the growth of tumour cells. The human cDNA contains a single open reading frame encoding a protein of 153 amino acids, including a putative signal peptide. It may act as an autocrine growth factor in pancreatic cancer cells and also give rise to the possibility that cancer-derived IL-4 may suppress cancer-directed immunosurveillance in vivo, in addition to its growth-promoting effects, thereby facilitating pancreatic tumor growth and metastasis. The mouse and human genes and their protein products show structural and functional similarities. The human gene, which occurs as a single copy in the haploid genome, is mapped on chromosome 5.2

Leave a Reply

Your email address will not be published.